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Synaptic short-term plasticity at mossy fiber to CA3 pyramidal cell synapses

3D Technology Animations and Motion Pictures
Area of expertise: 
Neuroscience
Mossy Fiber Bouton
synaptic transmission
Hippocampus
Client reference: 
Dr Katalin Toth, Centre de Recherche de l'Institut Universitaire en Santé Mentale de Québec, Quebec

Dr Katalin Toth investigates the mechanisms governing synaptic short-term plasticity at mossy fiber to CA3 pyramidal cell synapses using a combination of state-of-the-art electrophysiological and imaging techniques. Their findings suggest that the combination of multivesicular release and the recruitment of additional release sites act together to increase glutamate release during burst activity. This is supported by the compartmentalized spatial profile of calcium elevations in boutons and helps to expand the dynamic range of mossy fibers information transfer.

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