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The Dopaminergic Synapse

3D Technology Animations and Motion Pictures
Area of expertise: 
Neuroscience
Parkinson's disease
Brain
Dyskinesia
Dopamine
Molecular
Synapse
Client reference: 
Dr Erwan Bezard, Institute for Neurodegenerative Disease, Bordeaux

Parkinson's disease is a complex health condition characterised by a degeneration of dopaminergic neurons of the brain. This movie explains the dynamics of molecular reorganisation occurring at the synaptic level after the loss of those neurons.

Accumulating evidence indicates that L-DOPA-induced dyskinesia is primarily caused by the sensitization of dopamine D1 receptor transmission in striatal medium spiny neurons. This phenomenon, combined with chronic administration of L-DOPA, leads to persistent and intermittent hyper-activation of the cAMP signaling cascade.
The movie produced in collaboration with Dr. Bezard pictures the precise molecular mechanisms taking place in healthy subject and their impairment in the parkinsonian condition including L-DOPA induced dyskinesia. Neurodegenerative illnesses such as Parkinson's Disease affect many human lives and communities from patients and their families to clinicians and researchers. Animation is a powerful tool to turn complex biological reality into meaningful graphics for the both scientist, patients and the general public.

Client testimonial: 
Scilight combines the in-depth knowledge of neuroscience with the mastering of state-of-the-art animation, turning your vague idea into a real piece of communication-ready fancy and yet accurate movie. A real pleasure interacting with such brilliant people.